Itachi Uchiha
Itachi Uchiha gained the Mangekyo Sharingan by killing his best friend, Shisui. With the Mangekyo Sharingan, Itachi was able to use at least three (and the most, as of yet) of the most powerful jutsu. The first was Tsukuyomi, an extremely powerful genjutsu that allowed him to torture opponents for what seemed like days in a matter of moments. The second technique was Amaterasu, a substantially potent ninjutsu, which creates virtually-inextinguishable black flames at the user's focal point that continue to burn until the target is reduced to ash. The last of these techniques was Susanoo, which allowed Itachi to summon a massive ethereal warrior. This entity fights on behalf of Itachi and shields him from all attacks, rendering Itachi essentially invincible.
All of these techniques use massive amounts of Itachi's chakra and, in addition to damaging his eyesight, put a great deal of strain in his body. During his final battle against Sasuke, Itachi's eyes were even shown bleeding after using the Mangekyo. He also told his brother that he wanted to take his eyes so that he can restore his eyesight and gain more power. During the resulting battle, Zetsu noted that Itachi's "Left Mangekyo" possessed the Tsukuyomi, while the "Right Mangekyo" possessed the Amaterasu.
Kakashi Hatake
Kakashi Hatake developed his own Mangekyo Sharingan during the time-skip. With his Mangekyo Sharingan, Kakashi mastered a technique that creates a localized inter-dimensional space-time ninjutsu called Kamui, allowing him to target any person and/or object and send it to another dimension. The attack requires considerable effort to aim precisely and appeared to leave Kakashi's chakra significantly drained; He collapses after using the technique three times even at full strength in a single day. How he awakened his Mangekyo Sharingan remains unknown, as he stated that everyone close to him was dead.Madara Uchiha
Madara Uchiha is the first Uchiha to gain the Mangekyo Sharingan. His Mangekyo took the form of a ring with three circular holes in it. He eventually grew blind from overusing it, and only by taking his younger brother Izuna's eyes did he regain his sight. This also gave him an "Eternal" Mangekyo Sharingan that gave him great power. His Eternal Mangekyo Sharingan looks identical in appearance to Madara's first Mangekyo combined with Izuna's Mangekyo.
Madara, posing as Tobi, has shown using an unnamed space/time ninjutsu which makes him nearly invulnerable and allows him to teleport to different places at will very quickly, but it's unclear if this is a result of his Mangekyo Sharingan. He may likely also be able to put out the so-called inextinguishable flames of Amaterasu quite easily.
In the past, Madara was able to use his Mangekyo Sharingan to control the Nine-Tailed Demon Fox like a pet. However, it has yet to be shown in the present.
Izuna Uchiha
Izuna Uchiha acquired his Mangekyo Sharingan soon after Madara did. His took the appearance of three bars stretching out of his pupil. Madara later took Izuna's eyes to regain his lost vision. In Madara's story, however, Izuna volunteered to give him his eyes for the clan's sake.Sasuke Uchiha
Sasuke Uchiha awakened his Mangekyo Sharingan after the death of his older brother, Itachi. Sasuke's Mangekyo takes the appearance of a six-sided star almost resembling the atomic model. Unlike other Sharingan, which have a black design and red background, Sasuke's Mangekyo is the first one that is shown to have a red design and a black background.
The first ability Sasuke has displayed using the Mangekyo is Amaterasu, which Itachi implanted within his eyes before his death. When Sasuke first used it unintentionally against Madara, his eyes take the appearance of Itachi's Mangekyo Sharingan. When he later uses it on his own, it takes the form of his own Mangekyo Sharingan. It has been noted that his skill with Amaterasu is even greater than Itachi's as he is able to control the flames with his right eye. He suffers from the same drawbacks from using it as Itachi did, as his eye strained to the point of bleeding, as well as his eyesight gradually began to deteriorate. He can also put out Amaterasu.
Sasuke has displayed the ability to use Susanoo, which he can manifest as a mere rib cage or a full form capable of attacking others. Sasuke has also been seen using genjutsu with his Mangekyo Sharingan on two occasions that boast similar effects as Tsukiyomi. As with Itachi's version, they are powerful enough to break down the will of the intended victim, and even cause paralysis.[2][3] However, they have not been named so it is unclear if they are the same.
Unlike Itachi, Sasuke's Amaterasu (ninjutsu) comes from his left eye, and his genjutsu comes from his right eye, along with his ability to manipulate and extinguish the black flames.